Upcoming Seminars
July 24, 2008
ITERATIVE COMPILATION BY EXPLORATION OF KERNEL DECOMPOSITION
Dr W. Jalby
University of Versailles Saint Quentin
Past Seminars
May 19, 2008
Recent Advances in Computation Photography
Jingyi Yu, Assistant Professor
Computer and Information Science Department University of Delaware
May 7, 2008
Gauss' Law: What does it NOT say?
H. Brian Sequeira
Johns Hopkins University, Applied Physics Laboratory
April 30, 2008
Circuits with Light at the Nanoscale
Nader Engheta
H. Nedwill Ramsey Professor, University of Pennsylvania
Department of Electrical and Systems Engineering, Philadelphia, Pennsylvania
April 15, 2008
Vacuum Technology Seminar
Varian Inc. Vacuum Technologies
March 7, 2008
Microfluidic Cell Arrays for High Throughput Signal Pathway Profiling and Drug Screening
Professor Sihong Wang
Department of Biomedical Engineering, City University of New York
February 15,
Flow Control on the Micro-Scale
Dr. Benjamin Shapiro, Associate Professor
University of Maryland, Department of Aerospace Engineering
December 5, 2007
High Power Diode Lasers and Applications
Dr. Wei Gao, President and CTO
Axcel Photonics
November 30, 2007
Fascinating Rhythms:
Reverse Engineering Cortical Function from Changes in Brain Oscillations in Neurological and Psychiatric Disease
Leif Finkel, MD, PhD
University of Pennsylvania, Department of BioEngineering
November 26, 2007
Molecular Level Modeling and Dynamic Analysis of Biochemically Coupled Multicellular Systems
Michael Henson
University of Massachusetts Amherst
November 21, 2007
Nanostructures for Potential Signal Transduction Constructed via Molecular Self-Assembly
Dr. Darrin Pochen
University of Delaware, Materials Science and Engineering
November 19, 2007
Optimal Precoding for Multiple-Input Multiple-Output Gaussian Channels with Arbitrary Inputs
Dr. Fernando Perez-Cruz
Universidad Carlos III & Princeton University (joint work with Miguel Rodrigues and Sergio Verdu)
November 12, 2007
Random Control Bounds for Block Coded Transmission over Fading MIMO
Multiple Access Channel
November 7, 2007
Metal/Semiconductor Nanocomposites
Professor Joshua Zide
University of Delaware
November 2, 2007
Engineering Cancer Therapies:
Mathematical Modeling of Tumor Metabolism
and Therapeutic Efficacy
Professor Neil Forbes
University of Massachusetts Amherst
October 31, 2007
Finite Difference Delay
Dr. Xiaobo Wang
University of Delaware
October 19, 2007
Scheduling of Optimal Medication Strategies for Early HIV Infection
Professor Antonios Armaou
Pennsylvania State University
October 17, 2007
Is There Life on the Moon?
Professor Brian Sequeira
Johns Hopkins APL
April 30, 2007
Distributed Processing over Adaptive Networks
Professor Ali H. Sayed
University California, Los Angeles
April 9, 2007
Thoughts on Innovation
Ray Sokola,
Chief Technology Officer Motorola Inc.
Monday, March 12, 2007
Packet Switching Comes of Age: From Research to Commercial Development
Dr. W. David Sincoskie
March 5, 2007
Wireless Sensor Networks
Professor Edward Coyle,
Purdue University
Wednesday February 14, 2007
Confessions of an Internet Timekeeper
Dr. David L. Mills
The University of Delaware, Department of Electrical and Computer Engineering
Microfluidic Cell Arrays for High Throughput Signal Pathway Profiling and Drug Screening
Professor Sihong Wang
Department of Biomedical Engineering,
City University of New York
11:15 AM Evans Hall, Room 204
Abstract:
Modern medicine reveals that dynamics of gene expression are fundamental to the coordination of cellular responses of complex diseases. Measurement of temporal gene expression patterns is currently limited to destructive low-throughput techniques such as northern blot, RT-PCR, and DNA microarrays. In order to overcome those limitations, a high-throughput scalable experimental platform was developed. It combines microfluidic with molecular cloning of transcription factor binding elements tagged with fluorescent protein reporters. Importantly, this platform provides real-time characterization of gene expression in living cells. The microfluidic device uses integrated microvalve arrays to control row-seeding and column-stimulation of 256 nanoliter-scale bioreactors for a high density matrix of stimulus-response experiments. We demonstrated the device in the context of hepatic inflammation by making ~5000 single-time-point-measurements in each automated and unattended experiment. Currently, we are developing a prototype of apoptotic cell arrays with the 3D culture ability for the real time signaling study of apoptosis pathway and anti-cancer drug screening. This technology has the potential to make significant impacts in basic science, disease diagnostics, drug discovery and screening for therapeutic purposes.